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Relationship of selective complement markers with schizophrenia

Abdull Jalil, Mohd Asyraf and Abd Rahim, Nour El Huda and Mohd Noor, Hanisah and Ku Zaifah, Norsidah and A.Talib, Norlelawati (2021) Relationship of selective complement markers with schizophrenia. Journal of Neuroimmunology, 363. ISSN 0165-5728 (In Press)

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Abstract

Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patients and 212 controls. C3 and C4 levels were significantly higher in the patients and in subjects with elevated C-reactive protein (CRP), and positively correlated with body mass index (BMI) (p <0.05). Schizophrenia, BMI, and CRP were significant predictors for C3 and C4 levels in multivariate analyses (p <0.001). In conclusion, complements C3 and C4 are potential peripheral biomarkers in schizophrenia.

Item Type: Article (Journal)
Additional Information: 7013/95714
Uncontrolled Keywords: Complement C3, Complement C4, C-reactive protein, Schizophrenia
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Dr Mohd Asyraf Abdull Jalil
Date Deposited: 30 Dec 2021 15:56
Last Modified: 12 Jan 2022 10:58
URI: http://irep.iium.edu.my/id/eprint/95714

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