The role of DRD4 DNA methylation in schizophrenia

Abd. Rahim, Nour El Huda and Rahim Mohd, Nabil Fikri and Ku Zaifah, Norsidah and Mohd Noor, Hanisah and Abdull Jalil, Mohd Asyraf and A.Talib, Norlelawati (2021) The role of DRD4 DNA methylation in schizophrenia. In: Medical Research Symposium 2021, 14 December 2021, Kuantan, Pahang. (Unpublished)

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Abstract

Introduction: DRD4 is a dopamine receptor subtype that has been linked to schizophrenia genetically. Previous studies have shown that the density of DRD4 in schizophrenics' brains was higher than the other dopamine receptors. However, the genetic research of DRD4 in the physiology of the dopaminergic system with increased risk of schizophrenia is still not well established. Due to the complexity of the gene variations associated with schizophrenia and the influence of environmental factors, the study aimed to analyse the DRD4 DNA methylation in the peripheral blood of schizophrenia. Materials and Methods: This study was a casecontrol study. A total of 138 schizophrenia patients were recruited from the Psychiatry Clinic, Hospital Kuantan Ampuan Afzan, Kuantan Pahang and 132 matched healthy controls were included from Kuantan district. The genomic DNA from the peripheral blood was extracted and bisulfite converted. The MethyLight Taqman® test was used to determine the degree of DRD4 DNA methylation quantitatively. The data was analysed using analysis of covariance (ANCOVA) after being adjusted for age and gender. Results: When compared to the control group, schizophrenia had significantly lower DRD4 DNA methylation (p=0.001). Males (p=0.026) and females (p=0.004) patients both had hypomethylation. Conclusion: This research strongly suggests that DNA methylation of the DRD4 gene may have a role in the genetic foundation of schizophrenia.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6300/95393
Uncontrolled Keywords:	DNA methylation, Schizophrenia, DRD4
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr Nour El Huda Abd Rahim
Date Deposited:	28 Dec 2021 12:16
Last Modified:	28 Dec 2021 22:55
URI:	http://irep.iium.edu.my/id/eprint/95393

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