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An experimental model of induction of osteoarthritis in New Zealand white rabbit

Abd. Rahim, Nour El Huda and Zulkifly, Ahmad Hafiz and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli and Amri, Fathonah and Hassan, Habibah and Mohd Zohari, Sarah Haryati and Abu Hassan, Salmah Anim (2021) An experimental model of induction of osteoarthritis in New Zealand white rabbit. In: Medical Research Symposium 2021, 14 December 2021, Kuantan, Pahang. (Unpublished)

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Introduction: Historically, animal models for osteoarthritis have been established to facilitate the study of the pathogenesis of osteoarthritis and the potential medical treatment. The anterior cruciate ligament transection (ACTL) and partial meniscal resection model in rabbits have been widely used. The aim of the study was to establish a more effective surgical approach to induce knee osteoarthritis in New Zealand White Rabbits. Materials and Methods: This descriptive study was approved by the Institutional Animal Care and Use Committee (I-ACUC) ethical committee. The surgical approach of induction of osteoarthritis was done in Advanced Orthopedics Research Laboratory, International Islamic University Malaysia. Eight rabbits underwent lateral and medial meniscectomies at bilateral foreleg knees to induce osteoarthritis. The models were examined through physical and radiographic analysis. Results: Physical exams showed that all model animal daily food and water intakes were normal. Animal model knee motion in passive range showed limitation and instability. Radiographic imaging analysis showed osteoarthritic changes in all models. Moreover, no mortality was recorded during the study. The approach requires less surgery time and easier access. The analgesia was more humane and showed faster recovery. Conclusion: These outcomes suggested an effective and feasible technique of inducing knee osteoarthritis in New Zealand White rabbit models.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 6300/95391
Uncontrolled Keywords: Osteoarthritis, New Zealand White Rabbit, Model
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: Dr Nour El Huda Abd Rahim
Date Deposited: 28 Dec 2021 10:45
Last Modified: 28 Dec 2021 10:45
URI: http://irep.iium.edu.my/id/eprint/95391

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