Continuous glucose monitoring system versus self-monitoring blood glucose in Type 1 Diabetes Mellitus children: a randomised controlled trial (RoSEC)

Muhd Helmi, Muhd Alwi and Bachok, Norsaadah and Hussain, Suhaimi (2021) Continuous glucose monitoring system versus self-monitoring blood glucose in Type 1 Diabetes Mellitus children: a randomised controlled trial (RoSEC). Malaysian Journal of Paediatrics and Child Health, 27 (2). pp. 51-68. ISSN 1511-4511

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Abstract

Objectives: The primary and secondary objectives were to compare the glycaemic control and frequency of hypoglycaemia between continuous glucose monitoring system (CGMS) and self-monitoring blood glucose (SMBG). Methods: A single centre, randomised, parallel-group controlled trial was conducted involving twenty-two type one Diabetes Mellitus (T1DM) patients with the mean age of 13.8 years assigned to either intervention or control group. All respondents wore the CGMS device at the beginning of the study. Intervention group (n=11) had their insulin adjusted based on the CGMS data, while the control group (n=11) was based on SMBG. Monthly average blood sugar level (BSL) and monthly mean hypoglycemic events per week (HE/wk) were measured at baseline, first month, second month, and third month. HbA1c levels were measured at baseline and in the third month. Results: The baseline characteristics were similar. The data were analysed using repeated measure analysis of variance (ANOVA). The mean difference of HbA1c within the group was not statistically significant with p=0.322. There were significant differences in the monthly mean HE/wk within and between groups, p=0.004, and p=0.037. Conclusion: In conclusion, CGMS is equivalent to SMBG in optimising glycaemic control but is more effective in detecting hypoglycaemia in children.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Continuous Glucose Monitoring System, Self-monitoring Blood Glucose, Type 1 Diabetes
Subjects:	R Medicine > RJ Pediatrics R Medicine > RJ Pediatrics > RJ101 Child Heatlh. Child health services. Preventive health services for children
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Paediatrics
Depositing User:	Dr Muhd Alwi Muhd Helmi
Date Deposited:	24 Dec 2021 09:30
Last Modified:	24 Dec 2021 09:30
URI:	http://irep.iium.edu.my/id/eprint/95211

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