Bioengineering of virus-like particles as dynamic nanocarriers for in vivo delivery and targeting to solid tumours

Mohamed Suffian, Izzat Fahimuddin and Al-Jamal, Khuloud T. (2021) Bioengineering of virus-like particles as dynamic nanocarriers for in vivo delivery and targeting to solid tumours. Advanced Drug Delivery Reviews, 180. pp. 1-19. ISSN 0169-409X E-ISSN 1872-8294

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Abstract

Virus-like particles (VLPs) are known as self-assembled, non-replicative and non-infectious protein particles, which imitate the formation and structure of original wild type viruses, however, lack the viral genome and/or their fragments. The capacity of VLPs to encompass small molecules like nucleic acids and others has made them as novel vessels of nanocarriers for drug delivery applications. In addition, VLPs surface have the capacity to achieve variation of the surface display via several modification strategies including genetic modification, chemical modification, and non-covalent modification. Among the VLPs nanocarriers, Hepatitis B virus core (HBc) particles have been the most encouraging candidate. HBc particles are hollow nanoparticles in the range of 30–34 nm in diameter and 7 nm thick envelopes, consisting of 180 or 240 copies of identical polypeptide monomer. They also employ a distinctive position among the VLPs carriers due to the high-level synthesis, which serves as a strong protective capsid shell and efficient self-assembly properties. This review highlights on the bioengineering of HBc particles as dynamic nanocarriers for in vivo delivery and specific targeting to solid tumours.

Item Type:	Article (Journal)
Additional Information:	7836/93994
Uncontrolled Keywords:	RNAi, Self-assembly, Protein, Nuclear imaging, HER2, Breast cancer SPECT/CT
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Izzat Fahimuddin Mohamed Suffian
Date Deposited:	22 Nov 2021 15:52
Last Modified:	22 Nov 2021 15:52
URI:	http://irep.iium.edu.my/id/eprint/93994

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