Mohd Shafri, Mohd Affendi and Ahmad Nadzirin, Izzuddin and Ruzaidee, Ahmad Hakimi and Ismail, Mohamad Adib
(2021)
An insight into Malay medical manuscript MSS 4016 and typhoid rever remedies.
Journal of Allied Health Sciences, 5 (5).
pp. 2476-2496.
E-ISSN 2600-8491
Abstract
Records of traditional Malay medicine to treat various diseases, including typhoid fever, are
contained in handwritten manuscripts. Typhoid, known in Malay as kepialu, is a bacterial infection
caused by Salmonella enterica serovar Typhi (S. Typhi). The infection could be treated in the past using
chloramphenicol, however chloramphenicol-resistant strain has emerged necessitating effort to find
new drug candidates against typhoid fever. This study aims to extract and analyse the content of a
Malay medical manuscript MSS 4016 pertaining to typhoid fever. The manuscript was first
transliterated from Jawi to Roman alphabets using standard philological system. The formulations for
typhoid fever were extracted and numbered. The ingredients were listed respective to each number.
Then, comparative analysis against modern research was performed using Google Scholar journal
database employing specific keywords such as the scientific names of plants and typhoid fever,
combined using Boolean Operators, in any time frame. From 66 diseases and 248 differing formulations
contained in the manuscript, 16 formulations were intended for typhoid fever involving the use of 63
types of plants. From the comparative analysis, 50 were reported in contemporary modern publications
as having various pharmacological activities related to typhoid. Thirty-four plants possess antibacterial
property and specifically 18 plants have been shown to inhibit the growth of S. Typhi such as Allium
cepa, Allium sativum and Nigella sativa. MSS 4016 is indeed an ancient pharmacopoeia holding a lot of
medicinal information on numerous diseases. The valuable information gathered from this study may
preserve knowledge in the manuscript while at the same time help in discovering potential plants for
typhoid treatments.
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