Cell viability study of star-shaped polymer hydrogel

Ismail, Mohamad Wafiuddin and Muhammad, Taher and Abd Hamid, Shafida and Wan Abdul Khodir, Wan Khartini and Daik, Rusli (2021) Cell viability study of star-shaped polymer hydrogel. In: Malaysian Polymer International Conference 2021, Universiti Kebangsaan Malaysia. (Unpublished)

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Abstract

The present study describes the preparation and evaluation of Carbopol formulation incorporated with star-shaped polymer containing PCL and PEG with ciprofloxacin as model drug cargo. The four arms star-shaped PCL-PEG (4PCG) and six arms star-shaped PCL-PEG (6PCG) were formulated to evaluate their capability in hydrogel formulation. Both formulations (4PCG and 6PCG) showed high drug entrapment efficiency (>95%) towards ciprofloxacin mainly due to hydrophobic-hydrophobic interaction between ciprofloxacin and PCL. The formulations were also tested on HGF-1 cell line to check their cell viability. Results showed that the cells maintained their high concentrations (>98%) indicating good biocompatibility.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	8895/93879
Uncontrolled Keywords:	star-shaped polymer, PCL-PEG, Ciprofloxacin.
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Mohamad Wafiuddin Ismail
Date Deposited:	07 Dec 2021 13:02
Last Modified:	30 Dec 2021 14:40
URI:	http://irep.iium.edu.my/id/eprint/93879

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