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Apoptotic activity of new oxisterigmatocystin derivatives from the marine-derived fungus aspergillus nomius NC06

Artasasta, Muh. Ade and Yanwirasti, Yanwirasti and Bakhtiar, M. Taher and Djamaan, Akmal and Ariantari, Ni Putu and Ru Angeli, Edrada Ebel and Handayani, Dian (2021) Apoptotic activity of new oxisterigmatocystin derivatives from the marine-derived fungus aspergillus nomius NC06. Marine Drugs, 19 (11). pp. 1-10. ISSN 1660-3397

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Abstract

Sponge-derived fungi have recently attracted attention as an important source of interest- ing bioactive compounds. Aspergillus nomius NC06 was isolated from the marine sponge Neopetrosia chaliniformis. This fungus was cultured on rice medium and yielded four compounds including three new oxisterigmatocystins, namely, J, K, and L (1, 2, and 3), and one known compound, asper- gillicin A (4). Structures of the compounds were elucidated by 1D and 2D NMR spectroscopy and by high-resolution mass spectrometry. The isolated compounds were tested for cytotoxic activity against HT 29 colon cancer cells, where compounds 1, 2, and 4 exhibited IC50 values of 1.21, 2.23, and 5.62 μg/mL, respectively. Under the fluorescence microscope by using a double staining method, HT 29 cells were observed to be viable, apoptotic, and necrotic after treatment with the cytotoxic compounds 1, 2, and 4. The result shows that compounds 1 and 2 were able to induce apoptosis and cell death in HT 29 cells.

Item Type: Article (Journal)
Additional Information: 5209/93688
Uncontrolled Keywords: marine sponge-derived fungus; Neopetrosia chaliniformis; Aspergillus nomius; oxisterig-matocystin; cytotoxic activity; HT 29 colon cancer cells; apoptosis cells
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Muhammad Taher
Date Deposited: 15 Nov 2021 11:19
Last Modified: 30 Nov 2021 08:58
URI: http://irep.iium.edu.my/id/eprint/93688

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