Whole genome sequencing analysis of salmonella enterica serovar typhi: history and current approaches

Wan Makhtar, Wan Ratmaazila and Bharudin, Izwan and Samsulrizal, Nurul Hidayah and Yusof, Nik Yusnoraini (2021) Whole genome sequencing analysis of salmonella enterica serovar typhi: history and current approaches. Microorganisms, 9. pp. 1-15. E-ISSN 2076-2607

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Abstract

In recent years, the advance in whole-genome sequencing technology has changed the study of infectious diseases. The emergence of genome sequencing has improved the understanding of infectious diseases, which has revamped many fields, such as molecular microbiology, epidemiology, infection control, and vaccine production. In this review we discuss the findings of Salmonella enterica serovar Typhi genomes, publicly accessible from the initial complete genome to the recent update of Salmonella enterica serovar Typhi genomes, which has greatly improved Salmonella enterica serovar Typhi and other pathogen genomic research. Significant information on genetic changes, evolution, antimicrobial resistance, virulence, pathogenesis, and investigation from the genome sequencing of S. Typhi is also addressed. This review will gather information on the variation of the Salmonella enterica serovar Typhi genomes and hopefully facilitate our understanding of their genome evolution, dynamics of adaptation, and pathogenesis for the development of the typhoid point-of-care diagnostics, medications, and vaccines.

Item Type:	Article (Journal)
Additional Information:	8022/93151
Uncontrolled Keywords:	whole-genome sequencing;Salmonella entericaserovar Typhi (S. Typhi); typhoid; viru-lence; multidrug-resistant; comparative genomics
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Plant Science
Depositing User:	Dr Nurul Hidayah Samsulrizal
Date Deposited:	20 Oct 2021 12:22
Last Modified:	20 Oct 2021 12:22
URI:	http://irep.iium.edu.my/id/eprint/93151

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