A review on the relationship between matrix metalloproteinases (MMPS) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [timps]) and the success of an autologous arteriovenous fistula (AVF)

Abdul Rahman, Mohd Norhisham Azmi and Othman, Ahmad Faidzal (2021) A review on the relationship between matrix metalloproteinases (MMPS) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [timps]) and the success of an autologous arteriovenous fistula (AVF). IIUM Medical Journal Malaysia, 20 (4). pp. 111-119. ISSN 1823-4631 E-ISSN 2735-2285

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Abstract

Since its introduction by Brescia and Cimino in 1966, arteriovenous fistula has been regarded as the best vascular access for haemodialysis purposes. However, it’s not without any drawbacks which have cost over USD1 billion in the United States alone to rectify. Intimal hyperplasia has been shown to be a major contributory factor to this development. Intimal hyperplasia is a complex molecular process resulting in the unwarranted accumulation of contractile smooth muscle cells, myofibroblasts, fibroblasts, and macrophages. There is an increasing amount of evidence suggesting that matrix metalloproteinases (MMPs) and their natural inhibitors [(tissue inhibitors of matrix metalloproteinases (TIMPs)] play a pivotal role in the development of intimal hyperplasia. Our purpose in writing this review article is to examine these shreds of evidence and to suggest what future research questions need to be answered to further strengthen and clarify this relationship

Item Type:	Article (Review)
Additional Information:	6953/92941
Uncontrolled Keywords:	Matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, autologous arteriovenous fistula, success
Subjects:	R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Surgery Kulliyyah of Medicine
Depositing User:	Dr M N A Abdul Rahman
Date Deposited:	11 Oct 2021 12:29
Last Modified:	11 Oct 2021 12:29
URI:	http://irep.iium.edu.my/id/eprint/92941

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