Baba, Mohd Shukri and Mohamad Zin, Noraziah and Latip, Jalifah
(2019)
The assessment of 3-indole lactate as promising antimalarial agent fractionated from endophytic Streptomyces SUK10 in Shorea ovalis tree.
In: International Conference on Natural Products 2019, 26-28 March 2019, Hilton Hotel, Kuching.
(Unpublished)
Abstract
As the most threatening human parasitic disease, the malarial etiological agents were reported to be resistant against nearly all current antimalarial drugs. The endophytic Streptomyces that resides in plant generally have a huge potential as a source of novel bioactive compounds with medicinal and pharmaceutical properties. The objective of the study is to evaluate the antimalarial potential of bioactive compound fractionated from endophytic Streptomyces SUK10 isolated from the bark of Shorea ovalis tree against Plasmodium berghei NK65. The 1D 1H-13C, 2D 1H-1H NMR data and the comparison between AntiBase library, HR-LCMS analysis and antimalarial bioassay tests towards the crude extract of Streptomyces SUK10 evidenced that 3-indole lactate or 3-indole lactic acid (C11H11NO3) as a promising compound was involved in antimalarial activity. The four days suppression test (4DST) in male ICR strain mice (25-30 g, 6-8 weeks old) showed that 78.5 % of the inhibition rate by 3-indole lactate at 10 µg/kg body weight (bw) and 50 % of the treated mice had survived for more than 9 months post-infection. There was a positive relationship (p ≤ 0.05, n = 6) between the survival of the treated mice group and the ability to inhibit the parasites growth. The results for biochemical tests were significantly situated in the normal ranged and histologically, no abnormalities found on the selected vital organs. The findings in this study indicated that 3-indole lactate fractionated from endophytic Streptomyces SUK10 in the bark of Shorea ovalis tree has a stronger and promising antimalarial property as a new substance for antimalarial treatment.
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