Proniosomal delivery of aceclofenac

Bakhtiar, M. Taher and MF Sammour, Rana (2021) Proniosomal delivery of aceclofenac. In: International Conference on Contemporary Science and Clinical Pharmacy 2021, Online. (Unpublished)

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Abstract

A proniosomal system has served as a new drug delivery system that significantly enhances the bioavailability of drugs with low water solubility. Aceclofenac (ACE), a potent non-steroidal anti-inflammatory drug, is used to relieve pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. However, it is characterised by low bioavailability that limited its use. Hence, the application of the proniosomal system can improve the bioavailability of ACE. The present study was intended to develop an optimised proniosomal ACE formula by the use of different carriers. Three formulations of proniosomes were prepared by the slurry method using the 100 mg ACE, 500 mg Span 60, 250 mg Cholesterol with 1300 mg of different carriers, i.e., glucose (FN1), maltodextrin (FN2), and mannitol (FN3). The prepared proniosomes were characterised by fourier transform infrared analysis (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added. Meanwhile, the powder X-ray diffractometry (PXRD) confirmed the amorphous phase of the prepared proniosomes, and the surfactant layer was observed by scanning electron microscopy (SEM). A comparison between the two methods was made, and the results revealed the appropriateness of the paddle method. The in vivo study conducted using albino rats showed enhanced bioavailability of ACE when glucose and maltodextrin proniosomes were used as a carrier. Maltodextrin proniosomes exhibited fast absorption with 183% relative bioavailability compared to the pure drug, while glucose proniosomes demonstrated 112% relative bioavailability. It was concluded that the proniosomal system enhanced the bioavailability of ACE. The in vitro-in vivo correlation level A successfully built provided an overview of the predicted drug absorbed from the niosomal dosage form. Nonetheless, the proniosomes prepared were not stable in normal and accelerated conditions after three months. It was suggested that proniosomes should be stored at 4-5 °C, and more studies should be performed on proniosomal storing conditions. HPLC was used for all the required determinations, such as the niosomes EE, drug content, and in vitro and in vivo drug release. Lastly, it was concluded that ACE proniosomes were successfully prepared using different carriers, and maltodextrin proniosomes enhanced ACE bioavailability two-fold in comparison with the pure drug. Keywords: Aceclofenac; enhanced delivery; in vitro; in vivo; vesicle delivery.

Item Type:	Conference or Workshop Item (Keynote)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	14 Sep 2021 15:36
Last Modified:	14 Sep 2021 15:36
URI:	http://irep.iium.edu.my/id/eprint/92158

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