Screening of the cytotoxic activity of Aquilaria malaccensis aqueous extract against selected cancer cell lines towards development of halal and toyyib anticancer agent

Eissa, Manar and Hashim, Yumi Zuhanis Has-Yun and Mohd Salleh, Hamzah and Abd Warif, Nor Malia (2021) Screening of the cytotoxic activity of Aquilaria malaccensis aqueous extract against selected cancer cell lines towards development of halal and toyyib anticancer agent. In: Virtual International Halal Science Conference 21, 13th-14th July 2021, Kuala Lumpur.

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Abstract

Aquilaria malaccensis produces a fragrant agarwood resin in response to injury. Several studies have reported different pharmacological effects of Aquilaria malaccensis leaves including anticancer activity. This study aims at screening the cytotoxic effects of the aqueous extract of Aquilaria malaccensis leaves using WST-1 cytotoxicity assay against six cancer cell lines, breast cancer cell line (MCF-7), lung cancer (A-549), cervical cancer cell line (HeLa), colorectal cell line (HT-29), liver cancer cells (HepG2), and prostate cancer (PC-3). The extract demonstrated cytotoxic effect against the MCF-7 and A549 cell lines with IC50 values equal to 74.72 and 95.62 µg/mL, respectively, while in the other cell lines the IC50 was above 100 µg/mL. The study suggests the possible use of the aqueous extract of A. malaccensis leaves as a Halal and Toyyib therapeutic anticancer agent.

Item Type:	Conference or Workshop Item (Plenary Papers)
Uncontrolled Keywords:	Aquilaria malaccensis, agarwood, anticancer, cytotoxicity, WST-1, Halal and Toyyib
Subjects:	BPC Science and Technology in Islam
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	DR YUMI ZUHANIS HAS-YUN HASHIM
Date Deposited:	06 Sep 2021 10:02
Last Modified:	06 Sep 2021 10:39
URI:	http://irep.iium.edu.my/id/eprint/91977

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