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Levels of interleukins in patients with chronic kidney disease and periodontitis: a systematic review

Mahmud, Mohemmed and Jesmin, Fabiha and Kassim, Nur Karyatee and Zainuddin, Siti Lailatul Akmar and Hanafi, Muhammad Hafiz and Kamarudin, Muhammad Imran and Ahmad, Farizan and Kuttulebbai Naina Mohamed Salam, Sirajudeen (2021) Levels of interleukins in patients with chronic kidney disease and periodontitis: a systematic review. Journal of International Oral Health, 13 (4). pp. 313-318. ISSN 0976-7428 E-ISSN 0976-1799

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Aim: To systematically review the in vivo clinical studies available in the literature evaluating the effect of interleukin (IL) in patients with chronic kidney disease (CKD) and chronic periodontitis (CP). Materials and Methods: A search was initially performed using Scopus, PubMed, and Web of Science databases published from the year 2003 to 2020. Among the keywords used in the search were “periodontal diseases,” “interleukin,” “chronic kidney diseases,” and “inflammation.” After relevant articles were found, a critical assessment was made to select those that met the criteria for the systematic review. Among the inclusion criteria needed for the papers were randomized clinical trials, longitudinal clinical trials, clinical studies, no sample size limits, and only English language articles. Case reports, conference abstracts, and unpublished data were excluded for this study. Result: Based on the keywords, 16 of the relevant articles were listed and seven of them were selected for a systematic review. Conclusion: After reviewing the articles based on their results and conclusion, it can be concluded that serum IL level increased significantly in patients with CKD and CP and periodontal therapy can significantly reduce the level of serum IL. Moreover, the effect of modern periodontal therapy in CKD and CP is still unknown and inflammatory gene expression profile in patients with CKD will still need to be evaluated within different populations

Item Type: Article (Review)
Additional Information: 9547/91864
Uncontrolled Keywords: Inflammation, Chronic Kidney Diseases, Interleukin, Periodontal Diseases
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine
Depositing User: Mrs Norsyafini Ahmad Marzuki
Date Deposited: 01 Sep 2021 15:38
Last Modified: 01 Sep 2021 15:38
URI: http://irep.iium.edu.my/id/eprint/91864

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