Development of Ciprofloxacin-loaded PCL-PEG Hydrogel

Ahmad Shariff, Siti Hajar and Haris @ Harith, Muhammad Salahuddin and Ismail, Wafiuddin (2021) Development of Ciprofloxacin-loaded PCL-PEG Hydrogel. In: The 12th International Fundamental Science Congress 2021, 24 - 26 August 2021, Selangor. (Unpublished)

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Abstract

The incorporation of polymer blending into hydrogel formulation is expected to improve the drug loading and encapsulation efficiency of the hydrogel for skin application. Star-shaped polymer made up of poly(caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) has a great potential to be used as polymer blending in the hydrogel formulation as the PCL region can increase drug encapsulation through hydrophobic-hydrophobic interaction with the hydrophobic drug, and the PEG region can increase the solubility of the polymer to be used as a drug cargo in human body. In this study, two hydrogel formulations will be incorporated with different amount of 4-arm star-shaped PCL-b-PEG (4s PCL-b-PEG) to demonstrate drug loading percentage and drug encapsulation efficiency between the two formulations. The key ingredient of the hydrogel consists of the synthesized star-shaped PCL-b-PEG polymers as the drug cargo, along with Carbopol 940 as the gelling agent, ciprofloxacin as the hydrophobic drug model, methyl and propyl paraben as the preservatives, trifluoroethanol, triethylamine, and water. The drug loading and encapsulation efficiency of both formulations were found to be more than 99%, indicating high capability of the formulations as hydrophobic drug cargo.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	91797 / 6657
Uncontrolled Keywords:	Star polymer, PCL-PEG, Hydrogel formulation, Drug loading, Encapsulation Efficiency
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Mohamad Wafiuddin Ismail
Date Deposited:	06 Oct 2021 11:38
Last Modified:	06 Oct 2021 11:40
URI:	http://irep.iium.edu.my/id/eprint/91797

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