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Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

Akhlaq, Muhammad and Azad, Abul Kalam and Ullah, Inam and Nawaz, Asif and Safdar, Muhammad and Bhattacharya, Tanima and Helal Uddin, Abul Bashar Mohammed and Abbas, Syed Atif and Mathews, Allan and Kundu, Sukalyan Kumar and Miret, Mireia Mallandrich and Murthy, H. C. Ananda and Nagaswarupa, H. P. (2021) Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix. Polymers, 13 (14). pp. 1-17. ISSN 2073-4360

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Abstract

Abstract: The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate buffer (PBS) (pH 6.8 & pH 7.4) media. Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA) were performed to evaluate the chemical compatibility of the Gel/PVA hydrogel. The shape alteration and release of Gel/PVA hydrogel was conducted at pH 1.2, pH 6.8 and pH 7.4. The drug release kinetic mechanism was determined using various kinetic equations. The physicochemical evaluation tests and drug release profile results were found to be significant (p < 0.01). However, it was dependent on the polymers’ concentration, the pH of the release media and the amount of the cross-linking agent. Hydrogels containing the maximum amount of gel showed a dynamic equilibrium of 10.09 � 0.18 and drug release of 93.75 � 0.13% at pH 1.2. The kinetic models showed the release of MTX from the Gel/PVA hydrogel was non-Fickian.The results confirmed that the newly formed Gel/PVA hydrogels are potential drug delivery systems for a controlled delivery of MTX to the colon.

Item Type: Article (Journal)
Additional Information: Claim publication fee -sn 30/7/2021
Uncontrolled Keywords: Keywords: methotrexate; gelatin; polyvinyl alcohol; hydrogel; pH-responsive; targeted delivery; colon cancer
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 26 Jul 2021 10:16
Last Modified: 15 Oct 2021 16:46
URI: http://irep.iium.edu.my/id/eprint/91015

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