Loss of add1 methylation adds on blood pressure in young adults

Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2021) Loss of add1 methylation adds on blood pressure in young adults. Journal of Hypertension, 39. e259. ISSN 0263-6352 E-ISSN 1473-5598

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Abstract

Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were included in a cross-sectional study by purposive sampling. They were assessed for ADD1 methylation in peripheral blood using MethyLight assay. Anthropometric measurements and biochemical parameters were also examined. Results: ADD1 methylation was inversely correlated with systolic (p = 0.006, r = –0.240), diastolic (p = 0.001, r = –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive subjects had significantly higher ADD1 methylation than normotensive control (p = 0.005). After adjusting for other relevant covariates (age, body mass index, HbA1c, high-sensitivity C-reactive protein and low density lipoprotein cholesterol), ADD1 methylation remained a significant predictor for hypertension in young adults (p = 0.020) Conclusions: ADD1 methylation is a significant predictor of hypertension in young adults. ADD1 methylation could serve as a future preventive and therapeutic target for hypertension and related cardiovascular disease.

Item Type:	Article (Journal)
Subjects:	Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	16 Jul 2021 10:14
Last Modified:	16 Jul 2021 10:14
URI:	http://irep.iium.edu.my/id/eprint/90851

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