Randomized clinical trial comparing helmet continuous positive airway pressure (hCPAP) to facemask continuous positive airway pressure (fCPAP) for the treatment of acute respiratory failure in the emergency department

Adi, Osman and Via, Gabriele and Salleh, Siti Hafsah and Tan, Wan Chuan and Ab Rahman, Jamalludin and Nik Muhammad, Nik Azlan and Atan, Rafidah and Yunos, Nor'Azim (2021) Randomized clinical trial comparing helmet continuous positive airway pressure (hCPAP) to facemask continuous positive airway pressure (fCPAP) for the treatment of acute respiratory failure in the emergency department. American Journal of Emergency Medicine, 49. pp. 385-392. ISSN 0735-6757 E-ISSN 1532-8171

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Abstract

Study objective: To determine whether non-invasive ventilation (NIV) delivered by helmet continuous positive airway pressure (hCPAP) is non-inferior to facemask continuous positive airway pressure (fCPAP) in patients with acute respiratory failure in the emergency department (ED). Methods: Non-inferiority randomized, clinical trial involving patients presenting with acute respiratory failure conducted in the ED of a local hospital. Participants were randomly allocated to receive either hCPAP or fCPAP as per the trial protocol. The primary endpoint was respiratory rate reduction. Secondary endpoints included discomfort, improvement inDyspnea and Likert scales, heart rate reduction, arterial blood oxygenation, partial pressure of carbon dioxide (PaCO2), dryness of mucosa and intubation rate. Results: 224 patients were included and randomized (113 patients to hCPAP, 111 to fCPAP). Both techniques reduced respiratory rate (hCPAP: from33.56±3.07 to 25.43±3.11 bpmand fCPAP: from33.46±3.35 to 27.01± 3.19 bpm), heart rate (hCPAP: from 114.76 ± 15.5 to 96.17 ± 16.50 bpm and fCPAP: from 115.07 ± 14.13 to 101.19 ± 16.92 bpm), and improved dyspnea measured by both the Visual Analogue Scale (hCPAP: from 16.36 ± 12.13 to 83.72 ± 12.91 and fCPAP: from 16.01 ± 11.76 to 76.62 ± 13.91) and the Likert scale. Both CPAP techniques improved arterial oxygenation (PaO2 from 67.72 ± 8.06 mmHg to 166.38 ± 30.17 mmHg in hCPAP and 68.99±7.68mmHg to 184.49±36.38mmHg in fCPAP) and the PaO2:FiO2 (Partial pressure of arterial oxygen: Fraction of inspired oxygen) ratio from 113.6 ± 13.4 to 273.4 ± 49.5 in hCPAP and 115.0 ± 12.9 to 307.7±60.9 in fCPAP. The intubation ratewas lowerwith hCPAP (4.4% for hCPAP versus 18% for fCPAP, absolute difference −13.6%, p = 0.003). Discomfort and dryness of mucosa were also lower with hCPAP.

Item Type:	Article (Journal)
Additional Information:	3297/90733
Uncontrolled Keywords:	Non-invasive ventilation, Acute respiratory failure, Helmet CPAP, Facemask CPAP
Subjects:	R Medicine > R Medicine (General) R Medicine > RD Surgery > RD81 Anesthesiology R Medicine > RD Surgery > RD93 Emergency Surgery. Wounds and Injuries
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Depositing User:	nur hakimah a manan
Date Deposited:	14 Jul 2021 14:59
Last Modified:	14 Jul 2021 14:59
URI:	http://irep.iium.edu.my/id/eprint/90733

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