Mode of action of 5-acetyl-4-methylthiazole derivatives as antimicrobial agents

Abdullah Ripain, Iswatun Hasanah and Ngah, Nurziana and Darnis, Deny Susanti (2021) Mode of action of 5-acetyl-4-methylthiazole derivatives as antimicrobial agents. Malaysian Journal of Analytical Sciences, 25 (2). pp. 341-351. ISSN 1394-2506

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Abstract

Thiazole derivatives have been widely known to possess antimicrobial behaviour. The purpose of this study is to investigate the mode of antimicrobial actions of synthesised thiazole compounds on Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Salmonella typhimurium), and fungus (Candida albicans). Three synthesised thiazole compounds namely 5-acetyl-4-methyl-2-(3,4-dichloroaniline)-1,3-thiazole (T1), 5-acetyl-4-methyl-2-(4-aminophenol)-1,3-thiazole (T2), and 5-acetyl-4-methyl-2-(methyl-4-aminobenzoate)-1,3-thiazole (T3) were evaluated in the mode of action assays such as salt tolerance, time-killing, crystal violet and leakage 260/280 nm absorbing materials. The result showed that the T3 compound exhibited the best performance for all tested assays at a concentration equal to 4 × MIC compared to T1 and T2.

Item Type:	Article (Journal)
Uncontrolled Keywords:	thiazole, mode of action, antimicrobial
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Nurziana Ngah
Date Deposited:	06 Jul 2021 07:50
Last Modified:	06 Jul 2021 07:50
URI:	http://irep.iium.edu.my/id/eprint/90572

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