Proteomic profiling in Schizophrenia: a brief review

Abd. Rahim, Nour El Huda and Ku Zaifah, Norsidah and A.Talib, Norlelawati (2021) Proteomic profiling in Schizophrenia: a brief review. In: 3rd World Congress on Integration and Islamicisation 2021, 4th-6th June 2021, Virtual. (Unpublished)

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Abstract

Introduction: Proteomic profiling in schizophrenia was performed to elucidate significant biomarkers of this chronic complex disease. Any discovery of remarkably expressed proteins during the proteomic profiling is useful for translational studies and enhancement of basic science knowledge of schizophrenia. Due to recent advancement in different profiling approaches, review of available literature reporting proteomic analysis in schizophrenia in the last 10 years was performed. Method: Articles were retrieved following an advanced search in PubMed and SCOPUS limited to the English language published papers between 2000-2019 with the search keywords: “proteomics” and “schizophrenia”. Thirteen articles were relevant and extensively reviewed. Results: Collectively, the papers demonstrated that proteomics for schizophrenia research used brain tissues as well as blood specimens. There is evidence suggesting metabolism pathway in the development of schizophrenia which could be induced by antipsychotic drugs or independent of the drug treatment. Conclusion: This review indicates that proteomic profiling is a useful tool in identifying the potential metabolite biomarkers in schizophrenia. In addition, the findings of these studies may help in future research that will help the psychiatrists to select treatment options specifically tailored to obese schizophrenic patients.

Item Type:	Conference or Workshop Item (Poster)
Uncontrolled Keywords:	Proteomic, Glycolysis, Schizophrenia, Obesity
Subjects:	R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Nour El Huda Abd Rahim
Date Deposited:	16 Jul 2021 15:45
Last Modified:	16 Jul 2021 15:45
URI:	http://irep.iium.edu.my/id/eprint/90540

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