Hypotensive effects of aqueous extract of Eugenia polyantha leaves are partly mediated via cholinergic receptor

Ismail, Azlini and Sulaiman, Siti Amrah and Mohamed, Mahaneem and Syed Sahil Jamalullail, Syed Mohsin (2011) Hypotensive effects of aqueous extract of Eugenia polyantha leaves are partly mediated via cholinergic receptor. Conference Proceedings 16th National Conference on Medical and Heath Sciences. pp. 20-28. ISSN 978-967-5547-35-5

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Abstract

Eugenia polyantha leaves, a popular fresh salad (‘ulam’) used by the Kelantanese has been claimed as a cure for hypertension. In this study, the hypotensive effects of aqueous extract of Eugenia polyantha leaves (AEEP) on the anaesthetized male normotensive Wistar-Kyoto rats were described. Increasing intravenous doses of AEEP (0.01, 0.1, 1, 10 and 100 mg/kg) significantly reduced the mean arterial blood pressure (MAP) of twelve animals by 6.06 ± 4.1 %, 8.02 ± 3.9 %, 6.35 ± 0.6 %, 9.34 ± 1.6 % and 30.19 ± 2.0 % (Wilcoxon-Signed Rank test or WSR, p<0.01) respectively. However, only reductions in MAP, by the doses of 0.1, 1, 10 and 100 mg/kg of AEEP and by the positive control (5 µg/kg acetylcholine, 37.87 ± 1.7 %) were significantly higher than the reduction of MAP by the negative control (0.9 % normal saline, 5.372 ± 0.5 %) (WSR test, p<0.05). From the dose-response curve, the ED50 value for hypotensive effects of AEEP was 35.5 mg/kg. Subsequently, a pharmacological antagonistic study was carried out either of pre-treatment with propranolol (2 mg/kg) or by pre-treatment with atropine (2 mg/kg). Pre-treatment with atropine (2 mg/kg) significantly reduced the hypotensive effect of 100 mg/kg of AEEP (WSR test, p<0.05) whilst pre-treatment with propranolol (2 mg/kg) does not significantly reduced the hypotensive effect of 100 mg/kg AEEP (WSR test, p>0.05). This attenuation suggested that the hypotensive effect of AEEP may be partly mediated by cholinergic but not by β-adrenergic receptor pathways.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Eugenia polyantha, mean arterial blood pressure, dose-response curve, β-adrenergic receptor, cholinergic receptor, Syzygium polyanthum, hypertension, Malaysia
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM147 Administration of Drugs and Other Therapeutic Agents R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	DR. AZLINI ISMAIL
Date Deposited:	21 Jun 2021 22:25
Last Modified:	21 Jun 2021 22:25
URI:	http://irep.iium.edu.my/id/eprint/90204

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