IIUM Repository

Honey improves sperm parameters in high cholesterol diet-fed male rabbits

Hamad Mohamed, Zenab and Ibrahim, Muhammad and Hamad Alfarisi, Hamad Abdulsalam and Abdul Wahab, Azantee Yazmie and Abd. Fuaat, Azliana and Che Mohamad, Che Anuar (2021) Honey improves sperm parameters in high cholesterol diet-fed male rabbits. ASM Science Journal, 15. pp. 1-10. ISSN 1823-6782

[img] PDF (Article) - Published Version
Restricted to Registered users only

Download (322kB) | Request a copy


Overconsumption of a high-energy diet has a negative impact on sperm motility, morphology, vitality and concentration. Hence, this study aims to investigate the effects of honey on sperm parameters of high cholesterol diet-fed rabbits and compare its effects with atorvastatin. Forty-eight male New Zealand white rabbits were assigned into 6 groups: Control (C): commercial pellet; CH: commercial pellet and 600 mg/kg/day Trihoney; HCD: 1% cholesterol diet; DH1: 1% cholesterol diet and 300 mg/kg/day Trihoney; DH2: 1% cholesterol diet and 600 mg/kg/day Trihoney; DAt: 1% cholesterol diet and 2 mg/kg/day atorvastatin. After 12 weeks, each rabbit was anaesthetized. Sperm were obtained from the cauda of the epididymis. Percentages of progressive (PM) and total motility (TM) were assessed using light microscope. Vitality and morphology were assessed using Eosin-Nigrosin stain. Sperm concentration was calculated using haemocytometer. Administration of 1% cholesterol diet reduced the percentages of PM, TM and normal sperm. Treatment with atorvastatin reduced the percentages of PM, TM, live and normal sperm. A marked reduction in sperm concentration was detected in the HCD and DAt groups. Trihoney groups expressed significantly higher percentages of PM, TM, normal sperm, live sperm and sperm concentration than the HCD and DAt groups. These results indicate that Trihoney has the potential to minimize the negative impacts of a high cholesterol diet on sperm parameters.

Item Type: Article (Journal)
Additional Information: 4998/90175
Uncontrolled Keywords: High cholesterol, sperm parameters, trihoney, atorvastatin
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Obstetric & Gynecology
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User: salina mohammad
Date Deposited: 11 Jun 2021 13:00
Last Modified: 11 Jun 2021 13:00
URI: http://irep.iium.edu.my/id/eprint/90175

Actions (login required)

View Item View Item


Downloads per month over past year