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The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment

Razali, Khairiah and Othman, Noratikah and Mohd Nasir, Mohd Hamzah and Doolaanea, Abd Almonem and Kumar, Jaya and Ibrahim, Wisam Nabeel and Mohamed Ibrahim, Norlinah and Mohamed, Wael Mohamed Yousef (2021) The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment. Frontiers In Genetics, 12. pp. 1-17. ISSN 1664-8021

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Abstract

The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models.

Item Type: Article (Journal)
Additional Information: 7497/89368
Uncontrolled Keywords: zebrafish, neurodegenerative diseases, Parkinson’s disease, dopaminergic neuron, MPTP, animal model
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Nursing
Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science
Kulliyyah of Science > Department of Biotechnology
Depositing User: Dr Wael Mohamed
Date Deposited: 16 Apr 2021 14:12
Last Modified: 16 Apr 2021 14:12
URI: http://irep.iium.edu.my/id/eprint/89368

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