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A machine learning approach to assess magnitude of asynchrony breathing

Loo, Nienloong and Chiew, Yeong Shiong and Tan, Chee Pin and Mat Nor, Mohd Basri and Md Ralib, Azrina (2021) A machine learning approach to assess magnitude of asynchrony breathing. Biomedical Signal Processing and Control, 66. pp. 1-9. ISSN 1746-8094 E-ISSN 1746-8094

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Background: Conventional patient-ventilator interaction (PVI) assessment involves manual asynchronous index (AI) computation and incapable to provide in-depth information of the severity of asynchrony breathing (AB) during mechanical ventilation (MV). In this study, a novel convolutional autoencoder model (ABReCA) is developed to quantify the magnitude of AB as indicator of PVI. Method: ABReCA was trained with 400.000 unique AB to recognise its corresponding normal breathing (NB) cycle. The model then quantifies the severity of AB through comparison between identified NB waveform and AB. The magnitude of asynchrony (Masyn) is defined as the difference of a NB cycle affected by asynchronous patient’s effort. The performance of ABReCA was evaluated using K-folds analysis and used to measure the severity of AB in 10 mechanical ventilated respiratory failure patients. Results: K-fold analysis showed thatABReCA achieved high performance with only median 0.008 [Interquartile range (IQR): 0.007− 0.010] validation error. The model was able to recognise AB and its corresponding NB cycle. For the actual MV patient analysis, a typical AI counter shows a median of 32.7 % [IQR: 32.1–34.4] per patient. However, in our magnitude analysis, these patients experienced Masyn with mean of 3.8 % [IQR: 1.7 %–4.6 %]. The severity result is significantly lower compared to counting numbers alone as some AB are negligible while others have more impact towards the overall MV delivery. Conclusion: A novelABReCA is developed and capable of quantifying the severity of AB during MV. This model can potentially provide a better indication of the severity of AB and better reflection of the quality of PVI.

Item Type: Article (Journal)
Additional Information: 5608/89103
Uncontrolled Keywords: Convolutional autoencoder (CAE), Real-time, Asynchronous breathing, Patient-ventilator interaction
Subjects: R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User: Dr. Mohd Basri Mat Nor
Date Deposited: 31 Mar 2021 16:00
Last Modified: 31 Mar 2021 16:00
URI: http://irep.iium.edu.my/id/eprint/89103

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