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The phytochemistry and biological diversity of Ferulago genus (Apiaceae): a systematic review

Wan Salleh, Wan Mohd Nuzul Hakimi and Abed, Salam Ahmed and Bakhtiar, M. Taher and Kassim, Hakimi and Tawang, Alene (2021) The phytochemistry and biological diversity of Ferulago genus (Apiaceae): a systematic review. Journal of Pharmacy and Pharmacology, 73 (1). pp. 1-21. ISSN 0022-3573 E-ISSN 2042-7158

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Objectives The genus Ferulago belonging to the family Apiaceae is a flora widely distributed in Central Asia and the Mediterranean and used in folk medicine. It is administered as a sedative, tonic, digestive, aphrodisiac, also as a treatment for intestinal worms and haemorrhoids. Herein, we reported a review on phytochemistry and its biological activities reported from 1990 up to early 2020. All the information and reported studies concerning Ferulago plants were summarized from the library and digital databases (e.g. Scopus, Medline, Scielo, ScienceDirect, SciFinder and Google Scholar). Key findings The phytochemical investigations of Ferulago species revealed the presence of coumarins as the main bioactive compounds, including daucane derivatives, sesquiterpenes aryl esters, phenol derivatives, flavonoids and essential oils. Moreover, the therapeutic potentials of the pure compounds isolated from the genus Ferulago possess promising properties namely anticholinesterase, antimicrobial, anticoagulant, antileishmanial, antioxidant, antibacterial and antiproliferative. Summary Today, significant advances in phytochemical and biological activity studies of different Ferulago species have been revealed. The traditional uses and reported biological results could be correlated via the chemical characterization of these plants. All these data will support the biologists in the elucidation of the biological mechanisms of these plants.

Item Type: Article (Journal)
Additional Information: 5209/88675
Uncontrolled Keywords: Apiaceae; Ferulago; coumarin; sesquiterpene; essential oil; bioactivity
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Muhammad Taher
Date Deposited: 01 Mar 2021 13:20
Last Modified: 23 Jun 2021 15:23
URI: http://irep.iium.edu.my/id/eprint/88675

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