Progressive and persistent Increase in prevalence of methyldibromo glutaronitrile (MDBGN) contact sensitization from 2010 to 2018 in a tertiary center

Ismail, Rasimah and Jamil, Adawiyah and Md Nor, Norazirah (2019) Progressive and persistent Increase in prevalence of methyldibromo glutaronitrile (MDBGN) contact sensitization from 2010 to 2018 in a tertiary center. In: 15th Asia Pacific Environmental And Occupational Dermatology Symposium (APEODS) and the 44th Annual Dermatology Conference (ADC) of the Dermatological Society of Malaysia, 12th-15th September 2019, Royale Chulan Hotel, Kuala Lumpur. (Unpublished)

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Abstract

BACKGROUND: Contact sensitization allergens evolves periodically. Continual surveillance is necessary in order for clinicians to focus on current trend of allergen in contact dermatitis. Methods: This is a nine-year retrospective study on patch testing using European Baseline Series done on patients between 2010 to 2018 at Dermatology Unit, UKM Medical Centre. Results: There were 787 patients total. 70% were female and 30% were male. Mean age was 45 years old. 87% (725) of patients tested positive. Majority of cases were Malays (60.4%) followed by Chinese (23.4%) and Indians (6.2%). Cumulatively over 9 year period, the leading allergens were potassium dichromate (32.7%), methyldibromo glutaronitrile (MDBGN, 31.6%), nickel sulphate (30.6%) formaldehyde (29.1%) and fragrance mix (23.1%). Since 2014, MDBGN is on the emergence and is consistently the top allergen at our centre up till now with the highest rate of test positive 51% (2017).This was constantly followed by potassium dichromate (36%, 2018) and formaldehyde (34%, 2018). Conclusion: The emergence of MDBGN as chief sensitising agent is alarming and question should be raised on strict implementation of policies upon this banned substance.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	6383/88631
Uncontrolled Keywords:	Patch skin test, Methyldibromoglutaronitrile, MDBGN
Subjects:	R Medicine > RA Public aspects of medicine > RA644.3 Chronic and Noninfectious Diseases and Public Health R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC582 Specialities of Internal Medicine- Immunologic Diseases R Medicine > RL Dermatology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine
Depositing User:	Dr Rasimah Ismail
Date Deposited:	01 Mar 2021 11:11
Last Modified:	01 Mar 2021 11:11
URI:	http://irep.iium.edu.my/id/eprint/88631

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