Potential bioactivities of -mangostin from garcinia malaccensis Hk.f

Bakhtiar, M. Taher and Darnis, Deny Susanti and Solachuddin Jauhari, Arief Ichwan and Ahmad Zohri, Farah Syahidah and Nakazibwe, Sauba (2011) Potential bioactivities of -mangostin from garcinia malaccensis Hk.f. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 February 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM.

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Abstract

Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of α-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of α-mangostin. Its structural determination was done based on its spectroscopic analysis. α-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S. aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MIC) value was 0.025 mg/mL and minimum bactericidal concentration (MBC) value was 0.1 mg/mL, indicated that α-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of α-mangostin. In FTC method, α-mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has very weak scavenging effects on free radicals. In antiproliferative assay, -mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20 µg/mL. This study can form a foundation for future studies in investigating of biological activities of α-mangostin and developing the natural abundant in improving a healthy community.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5209/8796
Uncontrolled Keywords:	garcinia malaccensis, -mangostin, antibacterial, antioxidant, antiproliferative
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	13 Dec 2011 15:04
Last Modified:	09 Dec 2014 09:30
URI:	http://irep.iium.edu.my/id/eprint/8796

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