Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era

Ali, Kamal and Dassios, Theodore and Syed Abd Hamid, Syed Abdul Khaliq and Williams, Emma E. and Tamura, Kentaro and Davenport, Mark and Greenough, Anne (2019) Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era. Pediatric Surgery International, 35 (7). pp. 743-747. ISSN 0179-0358 (Unpublished)

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Abstract

Purpose To compare the outcomes of infants with a right (RCDH) versus a left-sided (LCDH) congenital diaphragmatic hernia (CDH) and whether these differed according to whether the infants had undergone fetoscopic tracheal occlusion (FETO). Methods Demographics, the type of surgical repair, preoperative and postoperative courses and respiratory, gastrointestinal, surgical and skeletal morbidities at follow-up were compared between infants with a RCDH or LCDH. A sub-analysis was undertaken in those who had undergone FETO. Results During the study period, there were 167 infants with a LCDH and 24 with a RCDH; 106 underwent FETO (15 RCDH). Overall, the need for inhaled nitric oxide (p = 0.036) was higher in the RCDH group and, at follow-up, infants with RCDH were more likely to have a hernia recurrence (p = 0.043), pectus deformity (p = 0.019), scoliosis (p = 0.029) and suffer chronic respiratory morbidity (p = 0.001). There were, however, no significant differences in short term or long term outcomes (hernia recurrence (p = 0.237), pectus deformity (p = 0.322), scoliosis (p = 0.0174) or chronic respiratory morbidity (p = 0.326)) between infants with a right or left sided CDH who had undergone FETO. Conclusion Overall, infants with a RCDH compared to those with a LCDH had greater long-term morbidity, but not if they had undergone FETO.

Item Type:	Article (Note)
Additional Information:	6261/87517
Uncontrolled Keywords:	Congenital diaphragmatic hernia · Survival · Follow-up · Hernia recurrence
Subjects:	R Medicine > RD Surgery R Medicine > RJ Pediatrics > RJ101 Child Heatlh. Child health services. Preventive health services for children
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Paediatrics
Depositing User:	Dr Syed Abdul Khaliq Syed Abd Hamid
Date Deposited:	08 Jan 2021 09:13
Last Modified:	08 Jan 2021 09:13
URI:	http://irep.iium.edu.my/id/eprint/87517

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