Abdul Mudalip, Siti Kholijah and Sezali, N A and Abu Bakar, Mohd Rushdi (2020) Effect of ultrasonic waves on polymorphism and crystal size distributions of mefenamic acid. In: 5th International Conference of Chemical Engineering and Industrial Biotechnology, ICCEIB 2020, 9th -11th August 2020, Kuala Lumpur, Malaysia.
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Abstract
Crystallization of pharmaceutical compound that have different polymorphic forms and broad crystal size distributions remain major challenge in industry. In this present work, the potential of ultrasonic intensifications on crystallization of mefenamic acid polymorph is investigated. The effect of sonication times (5 min – 30 min) and ultrasonic powers (153.3 – 766.7 Watt) at frequency of 65 kHz on polymorphic form and crystals size distributions (CSDs) of mefenamic acid crystals during cooling crystallization were investigated using One-Factor-At-a-Time method (OFAT). The polymorphic form, CSD and shape were determined using Fourier transform infrared spectroscopy (FTIR), Malvern Mastersizer, optical microscope and X-ray diffractometry, respectively. It was found that ultrasonic power of 766.7 Watt and 30 min of sonication time produce plate-shaped crystals with the narrow CSD. The polymorph was consistent with Form I. The findings justify the suitability of ultrasonic waves to produced platelike mefenamic acid Form I crystals with narrow CSD.
| Item Type: | Conference or Workshop Item (Plenary Papers) |
|---|---|
| Additional Information: | 4033/87487 |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology T Technology > TP Chemical technology T Technology > TP Chemical technology > TP155 Chemical engineering |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Dr Mohd Rushdi Abu Bakar |
| Date Deposited: | 02 Jan 2021 19:22 |
| Last Modified: | 17 Mar 2021 12:46 |
| URI: | http://irep.iium.edu.my/id/eprint/87487 |
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