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Cardioprotective effects of gallic acid on an isoprenaline-induced myocardial infarction rat model

Abdelhalim, Abdelbaset Taher and Mahmoud, Sayed A. M. and Nur, Nuruddin Mohammed and Mohamed, Mossad Abdelhak Shaban and Mansour, Sherif and Ibrahim, Suhaidah (2021) Cardioprotective effects of gallic acid on an isoprenaline-induced myocardial infarction rat model. International Journal of Nutrition, Pharmacology, Neurological Diseases (IJNPND). ISSN 2231-2722 E-ISSN 2231-0738 (In Press)

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Official URL: https://www.ijnpnd.com/

Abstract

The use of antioxidants to protect against a wide range of human disease, including ischemic heart disease, has moved to the forefront in cardiovascular research. Gallic acid has shown promising effects against oxidative stress-induced disease; however, its effect in ischemic heart disease has not been well-studied. We designed the current work to investigate the potential protective effect of gallic acid against isoprenaline (ISO)-induced myocardial infarction (MI). Rats were injected subcutaneously with ISO, 100 mg/ kg for 2 days, to induce MI. Gallic acid treated rats received 15 mg/ kg gallic acid orally for 10 days prior to ISO injection. The histopathological examination of the Haematoxylin and Eosin-stained heart sections from the ISO treated rats shows karyopyknosis, hypereosinophilia, loss of striation, infiltration of macrophage in the interstitium, and thrombosis of the blood vessels, all of which indicate the induction of MI. In addition, ISO treatment significantly increased the plasma level of malondialdehyde and troponin-I, as well as the activity of alanine aminotransferase, lactate dehydrogenase, and creatine kinase, compared to untreated controls. Pre-treatment with gallic acid significantly attenuated the ISO-induced biochemical and histopathological changes, compared to untreated controls. Our results show that ISO induced oxidative stress-mediated MI, and that gallic acid protects the rat heart from MI, at least in part, through antioxidant mechanisms.

Item Type: Article (Journal)
Additional Information: 8259/87303
Uncontrolled Keywords: Cardioprotective, gallic acid, myocardial infarction, oxidative stress.
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Paediatrics
Depositing User: Assoc.prof mossad shaban
Date Deposited: 07 Jan 2021 13:02
Last Modified: 07 Jan 2021 13:02
URI: http://irep.iium.edu.my/id/eprint/87303

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