4-arms poly (caprolactone) star-shaped polymer for drug delivery application: synthesis and characterization

Ahmad Shariff, Siti Hajar and Ismail, Mohamad Wafiuddin (2020) 4-arms poly (caprolactone) star-shaped polymer for drug delivery application: synthesis and characterization. In: Virtual Symposium on Sciences 2020 (VSoS 2020), 2nd November 2020, Universiti Tekanologi Mara (UiTM) Cawangan Negeri Sembilan. (Unpublished)

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Abstract

Star-shaped polymers have vast potential in bioapplication due to their architecture. In this study, 4 -arm star-shaped of poly(ԑ-caprolactone) (4s PCL) with -OH terminal and average molecular weight (Mn) of 5, 10, and 15 kDa, were synthesized via ring opening polymerization, (ROP) of ԑ-caprolactone (ԑ-CL) using a symmetric pentaerythritol (PET) as the core. Different molecular weight were obtained by using different ratio of ԑ-CL and PET in the presence of catalyst, stannous octoate (Sn(Oct)2). The FTIR spectra showed the presence of bands of methylene group of polymer repeating chain which confirm ROP of the ԑ-caprolactone. The molecular weight (Mn) determined from 1H NMR analysis showed that all 4s PCLs have approximately the same molecular weight as the theoretical values. TGA and DSC analysis showed a single step degradation for all 4s PCL and the crystallization melting point of the polymers within the range of melting point of PCL.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	8895/87263
Uncontrolled Keywords:	Star-shaped PCL, ROP, ԑ-caprolactone, bioapplication
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Mohamad Wafiuddin Ismail
Date Deposited:	31 Dec 2020 09:46
Last Modified:	31 Dec 2020 09:46
URI:	http://irep.iium.edu.my/id/eprint/87263

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