Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain

Mizher, Hussam and Zin, Che Suraya and Helal Uddin, A.B.M. and Mohamed, Rozilah @ Abdul Hadi and Tan, H Ling and Izzat, Munira (2020) Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain. Journal of Pharmacy and Bioallied Sciences, 12 (6). pp. 663-666. ISSN 0976-4879 E-ISSN 0975-7406

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Abstract

Introduction: Little is known whether the duration of opioid use influences the concentrations of pro- and anti-inflammatory cytokines. Objectives: This study examined the plasma concentration of pro-inflammatory cytokine, interleukin 6 (IL-6), and anti-inflammatory cytokine, interleukin 10 (IL-10), in short-, and long-term opioid users with noncancer pain. Materials and Methods: Adult patients with opioid therapy for noncancer pain were recruited from pain clinics at two tertiary hospital settings in Malaysia between February 2016 and March 2017. They were stratified into short- or long-term users based on opioid prescriptions ≥ 90 days per year. A 10 mL blood sample was taken for the analysis of plasma concentrations of IL-6 and IL-10 and were quantified using a highly sensitive multiplex assay. Results: Of 38 patients recruited, 24% (n = 9/38) and 76% (n = 29/38) were respectively short- and long-term opioid users. Short-term use of opioid was associated with higher levels of IL-6 (mean ± SD, 173.9 ± 13.7 pg/mL) and IL-10 (50 ± 5.8 pg/mL), whereas long-term use of opioids was associated with lower levels (no significant difference) of both cytokines IL6 (125 ± 16.1 pg/mL) and IL10 (41.3 ± 6.7 pg/mL). There was strong correlation between IL-6 and IL-10 within the same group (r² = 0.72, P < 0.05) and (r² = 0.76, P < 0.05) for short- and long-term users, respectively. Conclusion: The duration of opioid use may modulate the level of pro-inflammatory cytokines in which it was higher in short-term use and lower in long-term use, but the effect of pain relief was similar as both cytokines were well correlated

Item Type:	Article (Journal)
Additional Information:	4127/86960
Uncontrolled Keywords:	Cytokines, IL-10, IL-6, noncancer pain, opioid
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Prof Dr Che Suraya Mohd Zin
Date Deposited:	29 Dec 2020 10:27
Last Modified:	07 Nov 2022 10:18
URI:	http://irep.iium.edu.my/id/eprint/86960

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