Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine

Ibrahim, Maizatul Akma (2020) Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine. In: Virtual Symposium on Sciences 2020, 3rd November 2020, UiTM Kuala Pilah, Negeri Sembilan. (Unpublished)

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Abstract

Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacterial activity of the compounds was conducted by using the disc diffusion method and determination of minimal inhibitory concentration (MIC) as well as minimal bactericidal concentration (MBC). The results indicate that 4-fluorobenzoylthiourea α-alanine, benzoylthiourea α-alanine, 4-fluorobenzoylthiourea β-alanine, 4-chlorobenzoylthiourea β-alanine, 4-bromobenzoylthiourea β-alanine, and benzoylthiourea β-alanine possess weak to strong antibacterial activity on all of tested bacteria. The strongest antibacterial activity was found in the 4-fluorobenzoylthiourea α-alanine, whereas the weakest antibacterial activity was exhibited in 4-fluorobenzoylthiourea β-alanine. S. aureus was found the most susceptible toward these thiourea derivatives.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7138/86498
Uncontrolled Keywords:	benzoyl thiourea, halobenzoyl thiourea, antibacterial, disc diffusion test, minimum inhibition concentration
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Plant Science
Depositing User:	Dr Maizatul Ibrahim
Date Deposited:	15 Jan 2021 09:41
Last Modified:	15 Jan 2021 09:41
URI:	http://irep.iium.edu.my/id/eprint/86498

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