The association of serum adipokines and vitamin D level in newly diagnosed women with breast cancer: a case-control study

Zahali, Zunura’in and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Jan Mohamed, Hamid Jan (2020) The association of serum adipokines and vitamin D level in newly diagnosed women with breast cancer: a case-control study. In: 35th Nutrition Society of Malaysia (NSM) Scientific Conference, 24th-25th November 2020, Petaling Jaya, Selangor. (Unpublished)

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Abstract

This study was aimed to investigate the association of serum adipokines and vitamin D level with the risk of breast cancer. A case-control study was conducted on 78 women with newly diagnosed breast cancer and 86 healthy women, aged 21 to 59 years. Level of serum HMW adiponectin, visfatin, vitamin D and anthropometric parameters were determined. Mean serum adiponectin [2.9(1.6) vs 3.6(2.0)] and Vitamin D [14.5(7.5) vs 17.7(5.7)] concentrations were found significantly lower in cases group as compared to controls.group. The median serum visfatin of cases group was significantly higher than controls group [2.4(3.6) vs 1.7(2.1)]. Serum HMW adiponectin and vitamin D concentrations were found to be significantly associated with reduced risk of breast cancer (OR=0.79; 95% CI: 0.60-0.99, OR=0.90; 95% CI: 0.84-0.96). The risk of developing breast was 4.56-times (95% CI: 1.54-13.51) higher in women who had serum vitamin D <20 ng/ml as compared to those who had ≥20 ng/ml of serum vitamin D. Serum visfatin was seen to increase the risk of developing breast cancer in unadjusted model with OR=1.19 (95% CI: 1.01-1.39) although the association was insignificant after adjustments. We found that lower concentration level of HMW adiponectin and vitamin D may contribute to the development of breast cancer.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	Webinar Online Platform
Uncontrolled Keywords:	Serum adipokines, Vitamin D, Breast cancer risk
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	24 Dec 2020 08:42
Last Modified:	11 Jan 2021 12:56
URI:	http://irep.iium.edu.my/id/eprint/86302

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