Levetiracetam induced drug reaction with eosinophilia and systemic symptoms (DRESS)

Elengoe, Asita and Jamil, Adawiyah and Goh, Siew Wen and Arumugam, Mohan and Ismail, Rasimah and Periyasamy, Petrick (2019) Levetiracetam induced drug reaction with eosinophilia and systemic symptoms (DRESS). Brunei International Medical Journal, 15. pp. 140-144. ISSN 1560 5876 E-ISSN 2079 3146

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Abstract

Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug reaction characterized by rash, fever, lymphadenopathy and internal organ involvement. Levetiracetam, a non-aromatic anti-epileptic drug is generally considered to be safe. Levetiracetam induced DRESS is rare. We report a 62- year-old male treated with levetiracetam for seizures secondary to brain abscess. He developed fever followed by rash and mild hepatitis. The rash resolved with lower dose of levetiracetam but other features including eosinophil count continued to worsen. There was marked resolution of symptoms after discontinuation of levetiracetam and systemic corticosteroid therapy. Rapid diagnosis and immediate cessation of the culprit drug is key to treatment of DRESS.

Item Type:	Article (Case Report)
Additional Information:	6383/86119
Uncontrolled Keywords:	Anticonvulsants, Drug hypersensitivity reaction, Drug reaction with eosinophilia and systemic symptoms (DRESS), Hepatitis, Levetiracetam.
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC633 Specialties of Internal Medicines- Diseases of The Blood and Blood-forming Organs. Hematologic Diseases R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid R Medicine > RL Dermatology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Rasimah Ismail
Date Deposited:	14 Dec 2020 11:35
Last Modified:	14 Dec 2020 11:35
URI:	http://irep.iium.edu.my/id/eprint/86119

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