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Histopathological changes of the flaxseed extract on skin wound healing in diabetic rabbits

Mustafa Al-Ahmad, Basma Ezzat and Kashmola, Muhanad Ali Hamdon and Abdul Qader, Omar Abdul Jabbar and Mokhtar@Makhtar, Khairani Idah and Muhammad, Siti Aeshah @ Naznin and Abdul Rahim, Roslina and Mustafa, Nazih Shaban (2020) Histopathological changes of the flaxseed extract on skin wound healing in diabetic rabbits. Open Access Macedonian Journal of Medical Sciences, 8 (A). pp. 881-892. E-ISSN 1857-9655

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Abstract BACKGROUND: Wound healing includes phases such as cell migration, extracellular matrix deposition, remodeling, and angiogenesis. There are growing medicines that accelerate wound healing, significantly herbal medications that mainly safe and reliable. AIM: The aim of the study is to examine the histological changes induced by flaxseed oil during wound healing in diabetic animal model. METHODS: Forty-five male white New Zealand rabbits divided into two main groups diabetic and non-diabetic each group is divided into three groups (n = 9).Diabetic animal group include: (1) Study group (adding Flaxseed), (2) positive control group (adding fucidin 2% cream), and (3) negative control group (no treatment) same distribution of non-diabetic animals groups. Four linearshape,full-thickness wounds were made in both sides of the backbone skin in each animal. Tissue samples were obtained at days 4th, 7th, and 14th post wounding for microscopical analysis, histopathological parameters included inflammation, re-epithelialization, neovascularization, and surface closure rates. RESULTS: The study groups (using flax seed) in both diabetic and non-diabetic groups show significant reduction in inflammatory cells infiltration at day 14 (0.67 ± 0.753) (1.67 ± 0.516), and noticeable increase in wound closure rate (4.00+-0.000). Both diabetic and non-diabetic animal groups show high re-epithelialization potential at day 4 and day 7, respectively (2.00 ± 1.549; 4.00 ± 0.00). Diabetic animal study group using flaxseed shows high neovascularization rate at the day 14 (2.17 ± 0.753) compared with positive control diabetic animal group (2.00 ± 0.000). CONCLUSION: Topical application of flaxseed promoted healing process particularly in diabetic animal model by shortening inflammation phase, elevating surface closure rate, promoting re-epithelialization process, and enhancing neovascularization, flaxseed is suggested as a potential effective herbal base medication for facilitating wound healing.

Item Type: Article (Journal)
Additional Information: 5816/85727
Uncontrolled Keywords: Flaxseed, wound healing, diabetes, rabbit, histopathology
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Kulliyyah of Dentistry > Department of Oral Maxillofacial Surgery and Oral Diagnosis
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Dr Basma Al-Ahmad
Date Deposited: 02 Dec 2020 19:47
Last Modified: 06 Apr 2022 09:59
URI: http://irep.iium.edu.my/id/eprint/85727

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