In vitro model of the blood brain barrier

Mohd Nasir, Mohd Hamzah and Sharif, Mohd. Faez (2020) In vitro model of the blood brain barrier. In: In Vitro and In Vivo Techniques with Consideration of Biological System. Penerbit UTM Press, UTM, Johor, pp. 73-100. ISBN 978-983-52-1740-1 (In Press)

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Abstract

Neurons and other brain cells are extremely sensitive to changes in the macro- and micro-environment especially hydrostatic pressure (intracranial pressure) and electrolyte balance. Therefore, the brain macro- and micro-environment must be strictly maintained to its physiological balance. This can only be achieved by a functional gatekeeper serving as a selective barrier between fluids circulating to and from the brain. There are two primary circulatory fluids in the brain; first is the cerebrospinal fluid (CSF) and second is the blood fluid. Nutrient and biomolecule exchange between the blood and the CSF is regulated by the blood-CSF barrier, located at the choroid plexus. The other barrier that forms a selective permeable interface in the brain environment is the blood-brain barrier (BBB), which will be the primary focus of this chapter.

Item Type:	Book Chapter
Additional Information:	5522/85567
Uncontrolled Keywords:	BBB, HBEC, endothelial cell
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH501 Life
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr Mohd Hamzah Mohd Nasir
Date Deposited:	21 Dec 2020 10:29
Last Modified:	21 Dec 2020 10:30
URI:	http://irep.iium.edu.my/id/eprint/85567

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