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Serum cortisol and cardiometabolic parameters in young adults: does sex matter?

Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Abdullah, Aszrin and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah (2020) Serum cortisol and cardiometabolic parameters in young adults: does sex matter? In: Hypertension Seoul 2020 in conjunction with the 53rd Scientific Meeting of the Korean Society of Hypertension, Seoul, Korea. (Unpublished)

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Objectives: Young men are at higher cardiovascular risk compared to the female counterparts. Since cortisol could have a role in the pathophysiology of cardiometabolic syndrome, it could contribute to the observed intersex risk difference. The aim of this study is to examine the association between cortisol level and the cardiometabolic parameters in healthy male and female young adults. Methods: We analysed secondary data from an observational cross-sectional study conducted in 2017-2018. A total of 240 subjects aged 18 to 45 years from Kuantan were recruited via purposive sampling based on blood pressure status. Fasting blood was collected for serum cortisol, fasting blood glucose and HbA1c quantitation. Blood pressure parameters and anthropometry were recorded. Results: There was no significant difference in proportion of MetS in males and females (p = 0.175). Males had higher systolic (p < 0.001), diastolic (p = 0.015), mean arterial pressure (p < 0.001), cortisol (p = 0.001), and HbA1c (p = 0.004) compared to female young adults. In males, cortisol was associated with elevated blood pressure (p = 0.008). There was no significant association between cortisol to central obesity, low HDL cholesterol, hypertriglyceridaemia and impaired fasting glucose in both sexes. Conclusions: In male young adults, cortisol level was associated with raised blood pressure, suggesting that cortisol was unlikely to contribute to the higher cardiometabolic risk observed in young men. Further studies are warranted to delineate the underlying pathophysiology of metabolic derangement in young adults.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 7963/84967
Uncontrolled Keywords: Metabolic derangement, premetabolic state, syndrome X, hypercortisolism, cardiometabolic
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases
R Medicine > RC Internal medicine > RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Dr Wan Fatein Nabeila Wan Omar
Date Deposited: 26 Nov 2020 16:59
Last Modified: 26 Nov 2020 16:59
URI: http://irep.iium.edu.my/id/eprint/84967

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