A novel molecular imprint polymer quartz crystal microbalance nanosensor for the detection of andrographolide in the medicinal plant extract

Shafiqul Islam, A. K. M. and Krishnan, Hemavathi and Ahmad, Mohd Noor and Nadaraja, Pubalan and Helal Uddin, A.B.M. (2020) A novel molecular imprint polymer quartz crystal microbalance nanosensor for the detection of andrographolide in the medicinal plant extract. Russian Journal of Electrochemistry, 56 (12). pp. 1161-1169. ISSN 1023-1935 E-ISSN 1608-3342

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Abstract

A novel quartz crystal microbalance (QCM) sensor based on molecular imprint polymer (MIP) has been developed for the detection of andrographolide in the medicinal plant extracts. The MIP and non- imprinted polymer (NIP) were synthesized using a precipitation polymerization method. The polymers were characterized by Fourier-transform infrared spectrometry (FTIR), scanning electron microscopy (SEM) and cyclic voltammetry. Both MIP and NIP were deposited on quartz crystal platform using an electro-polymerization method. A linear Langmuir isotherm model revealed that the MIP-QCM sensor has the maximum binding sites 18.02 ng cm–2. It was found that 92.8% of andrographolide was detected in 0.10 μ g mL–1 of plant extract, and the limits of detection and quantification values were 1.21 ng cm–2 and 4.02 ng cm–2, respectively. This research showed that the andrographolide imprinted polymer could be used to detect and quantify andrographolide in Andrographis paniculata plant extract in both analytical separation and sensor development.

Item Type:	Article (Journal)
Additional Information:	4478/84857
Uncontrolled Keywords:	molecular imprint polymer, electropolymerization, andrographolide, quartz crystal microbalance
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	25 Nov 2020 15:07
Last Modified:	07 Jul 2022 15:25
URI:	http://irep.iium.edu.my/id/eprint/84857

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