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Investigation of filler effects on the compounding of freeze-dried orodispersible tablets containing Annona muricata extract

Noor Azman, Syahiera Ezzah and Abd Razak, Fashli Syafiq and Wan Kamal, Wan Hamirul Bahrin and Gan, Kok Zheng and Long, Chiau Ming and Helaluddin, Abul Bashar Mohammed and Sarker, Md. Zaidul Islam and Liew, Kai Bin (2020) Investigation of filler effects on the compounding of freeze-dried orodispersible tablets containing Annona muricata extract. International Journal of Pharmaceutical Compounding, 24 (6). pp. 513-518. ISSN 1092-4221

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Abstract

Orally disintegrating tablets are a solid dosage form that will disintegrate rapidly within 3 minutes upon contact with saliva. Fillers or diluents are excipients that are used to make up the volume of orally disintegrating tablets, and some might act as a disintegrant or binder that will affect the physical properties of orally disintegrating tablets. The objective of this study was to formulate and evaluate physical properties of orally disin- tegrating tablets containing Annona muricata leaves extract by a freeze- drying method using different fillers at different concentrations. In this study, fifteen formulations of orally disintegrating tablets were prepared by a freeze-drying method with different fillers such as starch, lactose, microcrystalline cellulose, StarLac, and CombiLac at 5%, 10%, and 15%. The orally disintegrating tablets were evaluated for hardness, thickness, weight variation, friability, and disintegration time test. The optimum formulation was chosen and incorporated with Annona muricata leaves extract. The results obtained in this work indicated that Formulation 3, with 15% starch, was the most optimum formulation due to the shortest disintegration time (21.08 seconds ± 4.24 seconds), and all the physical tests were within the acceptable range. The orally disintegrating tablets containing Annona muricata leaves extract possessed antioxidant activity and stable at least for 3 months under 60°C and 75% RH.

Item Type: Article (Journal)
Additional Information: 4478/84856
Uncontrolled Keywords: Annona muricata; orally disintegrating; orodispersible tablets
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 25 Nov 2020 09:17
Last Modified: 18 Jan 2021 11:12
URI: http://irep.iium.edu.my/id/eprint/84856

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