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Formulation development of paracetamol instant jelly for pediatric use

Almurisi, Samah Hamed and Doolaanea, Abd Almonem and Akkawi, Muhammad Eid and Chatterjee, Bappaditya and Aljapairai, Khater Ahmed Saeed and Sarker, Md. Zaidul Islam (2020) Formulation development of paracetamol instant jelly for pediatric use. Drug Development and Industrial Pharmacy, 46 (8). pp. 1373-1383. ISSN 0363-9045 E-ISSN 1520-5762 (In Press)

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Objective: Paracetamol is a common antipyretic and analgesic medicine used in childhood illness by parents and physicians worldwide. Paracetamol has a bitter taste that is considered as a significant barrier for drug administration. This study aimed to develop an oral dosage form that is palatable and easy to swallow by paediatric patients as well as to overcome the shortcomings of liquid formulations. Methods: The paracetamol was encapsulated in beads, which were prepared mainly from alginate and chitosan through electrospray technique. The paracetamol beads were sprinkled on the instant jelly prepared from glycine, ι-carrageenan and calcium lactate gluconate. The paracetamol instant jelly characteristics, in terms of physical appearance, texture, rheology, in vitro drug release and palatability were assessed on a human volunteer. Results: The paracetamol instant jelly was easily reconstituted in 20 mL of water within 2 min to form jelly with acceptable consistency and texture. The jelly must be ingested within 30 min after reconstitution to avoid the bitter taste. The palatability assessment carried out on 12 human subjects established the similar palatability and texture of the paracetamol instant jelly dosage comparable to the commercial paracetamol suspension and was found to be even better in overcoming the aftertaste of paracetamol. Conclusion: Such findings indicate that paracetamol instant jelly will compensate for the use of sweetening and flavouring agents as well as develop paediatric dosage forms with limited undesired excipients.

Item Type: Article (Journal)
Additional Information: 7245/84684
Uncontrolled Keywords: Beads; jelly; taste masking; Paracetamol; palatability
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Dr. Abd Almonem Doolaanea
Date Deposited: 25 Nov 2020 15:44
Last Modified: 25 Nov 2020 15:44
URI: http://irep.iium.edu.my/id/eprint/84684

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