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Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the Malaysian public setting

Rozali, Mohammad Azrai and Ab Rahman, Norny Syafinaz and Sulaiman, Helmi and Abd Rahman, Nurul Azrin and Atiya, Nadia and Wan Mat, Wan Rahiza and Jamaluddin, Mohd Fadhil and Mazlan, Mohd Zulfakar and Mat Nor, Mohd Basri and Hasan, Mohd Shahnaz and Abdul-Aziz, Mohd Hafiz (2020) Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the Malaysian public setting. Journal of Pharmacy and Bioallied Sciences, 12 (6). pp. 804-809. ISSN 0976-4879 E-ISSN 0975-7406

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Introduction: Approach to managing infection in the intensive care unit (ICU) often varies between institutions and not many readily adapt to available local guidelines despite it was constructed to suite local clinical scenario. Malaysia already has two published guidelines on managing infection in the ICU but data on its compliance are largely unknown. Objectives: A cross-sectional survey was carried out and sent to a total of 868 specialists working primarily in the ICU. The aim of this study was to explore knowledge, perception, and the antibiotic prescribing practice among specialists and advanced trainees in Malaysian ICU. Materials and Methods: A cross-sectional survey was used, consisted of three sections: knowledge, perception, and antibiotic prescribing practice in ICU. Three case vignettes on hospital-acquired pneumonia (HAP), infected necrotizing pancreatitis (INP), and catheter-related bloodstream infection (CRBSI) were used to explore antibiotic prescribing practice. Results: A total of 868 eligible subjects were approached with 104 responded to the survey. Three hundred eighty-nine antibiotics were chosen from seven different classes in the case vignettes. All respondents acknowledged the importance of pharmacokinetic/pharmacodynamic (PK/PD) in antibiotic optimization and majority (97.2%) perceived that current dosing is inadequate to achieve optimal PK/PD target in ICU patients. Majority (85.6%) believed that antibiotic dose should be streamlined to the organisms’ minimum inhibitory concentration (MIC). In terms of knowledge, only 64.4% provided the correct correlations between antibiotics and their respective PK/PD targets. Compliance rates in terms of antibiotic choices were at 79.8%, 77.8%, and 27.9% for HAI, INP, and CRBSI, respectively. Conclusion: Malaysian physicians are receptive to use PK/ PD approach to optimize antibiotic dosing in ICU patients. Nonetheless, there are still gaps in the knowledge of antibiotic PK/PD as well as its application in the critically ill, especially for β-lactams.

Item Type: Article (Journal)
Additional Information: 8789/84513
Uncontrolled Keywords: Antibiotic, β-lactams, critically ill patients, pharmacokinetic/ pharmacodynamic, survey
Subjects: R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
R Medicine > RM Therapeutics. Pharmacology > RM147 Administration of Drugs and Other Therapeutic Agents
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Date Deposited: 12 Nov 2020 10:09
Last Modified: 12 Nov 2020 10:12
URI: http://irep.iium.edu.my/id/eprint/84513

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