IIUM Repository

A narrative review of antimicrobial stewardship interventions within in-patient settings and resultant patient outcomes

Shirazi, Ovais Ullah and Ab Rahman, Norny Syafinaz and Zin, Che Suraya (2020) A narrative review of antimicrobial stewardship interventions within in-patient settings and resultant patient outcomes. Journal of Pharmacy and Bioallied Sciences, 12 (4). pp. 369-380.

[img] PDF - Published Version
Restricted to Registered users only

Download (96kB) | Request a copy


The overuse of antibiotics has led to various healthcare problems such as the emergence of resistance in infectious microbes and mortality due to antibiotic resistant healthcare associated infections (HAIs). An antimicrobial stewardship (AMS) program is the set of interventions used worldwide to enhance the rational use of antibiotics especially for the hospitalized patients. This review aimed to describe the characteristics of the implemented AMS programs in various hospitals of the world mainly focusing on the interventions and patients outcomes. The literature about AMS program was searched through various databases such as PubMed, Google Scholar, Science Direct, Cochran Library, Ovid (Medline), Web of Science and Scopus. In this review the literature pertaining to the AMS programs for hospitalized patients is sorted on the basis of various interventions that are categorized as formulary restriction (pre-authorization), guideline development, clinical pathway development, educative interventions and prospective audit. Moreover a clear emphasis is laid on the patient outcomes obtained as a result of these interventions namely the infection control, drop in readmission rate, mortality control, resistance control and the control of an overall cost of antibiotic treatment obtained mainly by curbing the overuse of antibiotics within the hospital wards. AMS program is an efficient strategy of pharmacovigilance to rationalize the antimicrobial practice for hospitalized patients as it prevents the misuse of antibiotics, which ultimately retards the health threatening effects of various antibiotics.

Item Type: Article (Review)
Additional Information: 5221/83852
Uncontrolled Keywords: Antimicrobial stewardship, in-patient, hospital, patient outcomes
Subjects: R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Date Deposited: 23 Oct 2020 14:10
Last Modified: 23 Oct 2020 14:10
URI: http://irep.iium.edu.my/id/eprint/83852

Actions (login required)

View Item View Item


Downloads per month over past year