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A new xanthone dimer and cytotoxicity from the stem bark of calophyllum canum

Bakhtiar, M. Taher and Wan Salleh, Wan Mohd Nuzul Hakimi and Alkhamaiseh, Suhaib Ibrahim and Ahmad, Farediah and Rezali, Mohd Fazlin and Darnis, Deny Susanti and Hasan, Choudhury Mahmood (2020) A new xanthone dimer and cytotoxicity from the stem bark of calophyllum canum. Zeitschrift für Naturforschung C, 1 (2). pp. 87-91. ISSN 0939-5075 E-ISSN 1865-7125

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A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1–3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC50 > 50 μM).

Item Type: Article (Note)
Additional Information: 5209/83074
Uncontrolled Keywords: Biscaloxanthone; Calophyllum canum
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science
Depositing User: Dr Muhammad Taher
Date Deposited: 21 Sep 2020 13:49
Last Modified: 08 Mar 2021 12:18
URI: http://irep.iium.edu.my/id/eprint/83074

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