The investigation of antioxidant and antidiabetic activities of Christia vespertilionis leaves extracts

Murugesu, Suganya and Perumal, Vikneswari and Balan, Tavamani and Fatinanthan, Sharon and Khatib, Alfi and Arifin, Norfarahanum Juhar and Mohd Shukri, Nur Syafiqah Salma and Saleh, Mohammed S.M. and Hin, Lee Wing (2020) The investigation of antioxidant and antidiabetic activities of Christia vespertilionis leaves extracts. South African Journal of Botany, 133. pp. 227-235. ISSN 0254-6299

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Abstract

The present study has been aimed to investigate the antioxidant and antidiabetic activities of Christia vespertilionis leaves extracts. The analysis of the extracts obtained using different solvents revealed that ethyl acetate: methanol extract as the most potential in 2, 2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging while hexane: ethyl acetate exhibited highest ferric reducing antioxidant power (FRAP) capacity and a-glucosidase inhibition. The infrared analysis displayed the presence of O-H, C-H, C=O, C=C, C-O, and N-H predominantly in the extracts reflecting some of the compounds reported previously; quercetin 3-O-glucoside, oleanolic acid methyl ester, b-sitosterol, stigmasterol, geraniol and 2’-hydroxygenistein. The latter two displayed competitive mode of inhibition in both the yeast and human protein receptors. Conclusively, C. vespertilionis leaves contain potent antioxidants and a-glucosidase inhibitors; thus, further studies can enhance its use in pharmaceutical applications.

Item Type:	Article (Journal)
Additional Information:	6915/82976
Uncontrolled Keywords:	Christia vespertilionis, a-Glucosidase inhibitory activity, Antioxidant, DPPH, FRAP, Saccharomyces cerevisiae
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	25 Sep 2020 15:15
Last Modified:	25 Sep 2020 15:15
URI:	http://irep.iium.edu.my/id/eprint/82976

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