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Probiotic inhibits oral carcinogenesis: A systematic review and meta-analysis

Wan Mohd Kamaluddin, Wan Nur Fatihah and Rismayuddin, Nurul Alia Risma and Ismail, Ahmad Faisal and Mohamad Aidid, Edre and Othman, Noratikah and Mohamad, Noor Afifah Hanin and Arzmi, Mohd Hafiz (2020) Probiotic inhibits oral carcinogenesis: A systematic review and meta-analysis. Archives of Oral Biology, 118. ISSN 0003-9969

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Abstract

Objectives: This systematic review aimed to investigate the effects if probiotics can inhibit oral carcinogenesis. Design: PubMed, Web of Science, Scopus, and PLOS databases were searched up to February 2020 to identify randomised controlled trials that fulfilled the eligibility criteria. Joanna Briggs Institute (JBI) Critical Appraisal Tool was used for quality assessment of articles. This review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 protocol guidelines. Result: The initial search retrieved 774 articles. Of these, only five articles were included in the qualitative synthesis. Two out of the five papers were further analysed for quantitative synthesis in meta-analysis. The majority of the included studies were found to be of “moderate quality”. The qualitative synthesis found four probiotics that exhibited potential therapeutic effects in oral carcinogenesis, includingAcetobacter syzygii, AJ2, Lactobacillus plantarum, and Lactobacillus salivarius REN. Among them, the application of L. salivarius REN re- sulted in a 95 % lower risk for developing oral cancer (p < 0.05). Conclusion: It is known that probiotics have the potential to inhibit oral carcinogenesis, thus supporting the hypothesis of the study. The ability of L. salivarius REN to inhibit the development of oral cancer suggested that this bacterium can be a potential inhibitory agent against oral carcinogenesis.

Item Type: Article (Review)
Additional Information: 7855/82826
Uncontrolled Keywords: Oral cancer; Probiotics; Lactobacillus plantarum, Lactobacillus salivarius, Acetobacter syzygii
Subjects: Q Science > QR Microbiology
R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Dentistry > Fundamental Dental and Medical Sciences
Kulliyyah of Dentistry > Paediatric Dentistry, Orthodontics & Dental Public Health
Kulliyyah of Nursing
Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User: Dr Mohd Hafiz Arzmi
Date Deposited: 23 Sep 2020 15:34
Last Modified: 23 Sep 2020 15:34
URI: http://irep.iium.edu.my/id/eprint/82826

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