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Association between pesticide exposure and childhood leukaemia: a systematic literature review of epidemiological studies

Sidek Ahmad, Zulkhairul Naim and Che Hasan, Muhammad Kamil (2020) Association between pesticide exposure and childhood leukaemia: a systematic literature review of epidemiological studies. International Journal of Care Scholars, 3 (1). pp. 23-36. ISSN 2600-898X

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Abstract

Introduction: Cancer is the leading cause of death for children and adolescents globally with 300,000 children aged 0-19 are diagnosed with cancer every year, mainly leukaemia, lymphomas and brain cancers. Like other causes of cancer, the difficulty arises because of multi-factorial aetiologies involving the interaction between genetic factors as well as environmental exposures. Aims: This study aimed to analyse published studies on the relationship between childhood leukaemia and exposures to pesticides. Methods: The search on the literature database Ovid-MEDLINE search strategy was conducted for the period from 1995 to 2014. The quality of non-randomised studies was assessed by using Newcastle Ottawa Scale (NOS). Results: Six studies investigated the relationship related to parental residential exposure and one study, showed an association between childhood leukaemia and maternal exposure. Two studies investigated the relationship to maternal residential exposure. Two studies reported an association between childhood leukaemia and parental occupational exposure. One study showed a positive association out of two studies that evaluated the association related to parental occupational and residential exposure. This review provides evidence of weak to modest association between childhood leukaemia and pesticides exposure in most of the studies. Conclusion: Most studies showed an association; however, the causation remains unexplained because of limitations such as potential bias, faulty study design and sample frame, lack of statistical power and also ascertainment of exposure.

Item Type: Article (Journal)
Additional Information: 5711/82601
Uncontrolled Keywords: Children, Pesticide, Exposure, Cancer, Leukaemia
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA644.3 Public Health. Hygiene. Preventive Medicine - Chronic and Noninfectious Diseases and Public Health
R Medicine > RJ Pediatrics
R Medicine > RT Nursing
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Nursing
Kulliyyah of Nursing > Department of Medical Surgical Nursing
Depositing User: Dr Muhammad Kamil Che Hasan
Date Deposited: 02 Sep 2020 14:52
Last Modified: 16 Feb 2021 15:45
URI: http://irep.iium.edu.my/id/eprint/82601

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