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Synthesis and characterization of orotic acid loaded chitosan inclusion complex

Hassani, Abdelkader and Azad, Abul Kalam and Enezei, Hamid H. and Hussain, Siti A. and Helaluddin, Abul Bashar Mohammed (2020) Synthesis and characterization of orotic acid loaded chitosan inclusion complex. International Journal of Drug Delivery Technology, 10 (1). pp. 1-4. ISSN 0975-4415

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Abstract

The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/ CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further. Keywords: Chitosan, Drug delivery, Inclusion complex, Orotic acid, Synthesis. International Journal of Drug Delivery Technology (2020); DOI: 10.25258/ijddt.10.1.1 How to cite this article: Hassani A, Azad AK, Enezei HH, Hussain SA, Helal Uddin ABM. Synthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex. International Journal of Drug Delivery Technology. 2020; 10(1): 1-4.

Item Type: Article (Journal)
Additional Information: 4478/82571
Uncontrolled Keywords: Chitosan, Drug delivery
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 10 Sep 2020 16:16
Last Modified: 16 Feb 2021 10:20
URI: http://irep.iium.edu.my/id/eprint/82571

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