Phytochemistry, traditional use and pharmacological activity of picrasma quassioides: a critical reviews

Mohd Jamil, Muhammad Daniel Hakim and Bakhtiar, M. Taher and Darnis, Deny Susanti and Rahman, Md Atiar and Zakaria, Zainul Amiruddin (2020) Phytochemistry, traditional use and pharmacological activity of picrasma quassioides: a critical reviews. Nutrients, 12 (2584). pp. 1-16. ISSN 2072-6643

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Abstract

Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals in P. quassioides and correlate their pharmacological activities with the significance of its use as traditional medicine. Data were collected by reviewing numerous scientific articles from several journal databases on the pharmacological activities of P. quassioides using certain keywords. As a result, approximately 94 phytochemicals extracted from P. quassioides were found to be associated with quassinoids, β-carbolines and canthinones. These molecules exhibited various pharmacological benefits such as anti-inflammatory, antioxidant, anti-cancer, anti-microbial, and anti-parasitic activities which help to treat different diseases. However, P. quassioides were also found to have several toxicity effects in high doses, although the evidence regarding these effects is limited in proving its safe use and efficacy as herbal medicine. Accordingly, while it can be concluded that P. quassioides may have many potential pharmacological benefits with more phytochemistry discoveries, further research is required to determine its real value in terms of quality, safety, and efficacy of use.

Item Type:	Article (Journal)
Additional Information:	5209/82482
Uncontrolled Keywords:	Picrasma quassioides; Simaroubaceae
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science
Depositing User:	Dr Muhammad Taher
Date Deposited:	09 Sep 2020 10:31
Last Modified:	10 Feb 2021 11:27
URI:	http://irep.iium.edu.my/id/eprint/82482

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