Adducin methylation and blood pressure in young adults ; less is more

Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2020) Adducin methylation and blood pressure in young adults ; less is more. In: Malaysian Society of Hypertension17th Annual Congress 2020, Shangri-La Hotel, Kuala Lumpur, Malaysia.

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Abstract

Background: Essential hypertension is a multifaceted disease implicating both genetic, environment and epigenetic modification. Whilst -Adducin (ADD1) polymorphism in essential hypertension has been previously described, modification in DNA methylation of ADD1 gene in hypertensive young adults is not known. Objective: To evaluate the association between ADD1 methylation and blood pressure in hypertensive young adults. Materials and methods: A cross-sectional study involving 80 normotension and 80 incident hypertension aged 18 to 45 years was conducted in Kuantan, Pahang. Subjects were recruited via purposive sampling according to blood pressure status. Anthropometric measurements and biochemical parameters (glycemic index, lipid profile, high- sensitivity C-reactive protein) were examined. ADD1 methylation in peripheral blood were assessed using MethyLight assay. Results: There were inverse correlation significant between ADD1 methylation and systolic blood pressure (p = 0.006, r = –0.240), diastolic blood pressure (p = 0.001, r= –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive young adults had significantly lower ADD1 methylation compared to normotensive controls (p = 0.005). After controlling for other baseline covariates, ADD1 methylation proved to be a significant predictor for hypertension in young adults (p = 0.020). Conclusion: In young adults, ADD1 methylation predicted hypertension. Thus, ADD1 methylation could serve as a future preventive and therapeutic target for hypertension, upkeeping the precision medicine notion.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7963/82003
Uncontrolled Keywords:	Adducin methylation ; blood pressure ; young adults
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	07 Aug 2020 16:46
Last Modified:	07 Aug 2020 16:46
URI:	http://irep.iium.edu.my/id/eprint/82003

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